Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma
نویسندگان
چکیده
منابع مشابه
Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma
Background. The prevalence of obesity has increased dramatically over the last decades, and its association with asthma is being increasingly recognized. Aims. Our hypothesis is that increased leptin and decreased adiponectin levels in obese subjects play a direct role in regulating inflammation in asthmatics. We wanted to examine the hypothesis that cysteinyl leukotrienes (cys-LT), inflammator...
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Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of allergic diseases such as asthma. CysLTs are potent bronchoconstrictors that have the additional effects of edema, mucous secretion, and eosinophilic accumulation, and airway remodeling. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as t...
متن کاملLeukotrienes in the pathogenesis of asthma.
Asthma is a chronic inflammatory disease that is associated with widespread but variable airflow obstruction. The mechanisms that lead to airflow obstruction in asthma are bronchoconstriction, mucosal edema, increased secretion of mucus, and an inflammatory-cell infiltrate that is rich in eosinophils. Leukotrienes (LTs) B4, C4, D4, and E4 have been shown experimentally to play a role in each of...
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Polyunsaturated fatty acids play a role as precursors of biologically active compounds that can act as mediators or modulators of various cell functions. Thus three main groups of derivatives the prostaglandins, the thromboxanes, and recently discovered leukotrienes are formed by oxygenation and further transformation of various polyunsaturated fatty acids of which arachidonic acid plays t...
متن کاملRole of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases
Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of...
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ژورنال
عنوان ژورنال: Journal of Allergy
سال: 2015
ISSN: 1687-9783,1687-9791
DOI: 10.1155/2015/157919